The American Revolution. That is according to GameInformer, who released details for the game quite early.
Whilst details of this can no longer be found on their website, early site viewers managed to spot a banner for Assassin’s Creed III and a poster, with the main assassin holding a hatchet, a shotgun and standing on a hill with the American flag. The game is expected for a November 2012 release.
Full details of the game will be revealed soon by Ubisoft, but for now, take a look at the poster below.
Click image to view.